Folate and Vitamin B12-Related Biomarkers in Relation to Brain Volumes
نویسندگان
چکیده
منابع مشابه
Folate and Vitamin B12-Related Biomarkers in Relation to Brain Volumes
AIM We investigated cross-sectional associations between circulating homocysteine, folate, biomarkers of vitamin B12 status and brain volumes. We furthermore compared brain volumes of participants who received daily folic acid and vitamin B12 supplementation with participants who did not. METHODS Participants of the B-PROOF study (n = 2919) were assigned to 400 µg folic acid and 500 µg vitami...
متن کاملFolate and vitamin B12.
The folates are made up of a pterdine ring attached to a p-aminobenzoate and a polyglutamyl chain. The active form is tetrahydrofolate which can have C1 units enzymically attached. These C1 units (as a formly group) are passed on to enzymes in the purine pathway that insert the C-2 and C-8 into the purine ring. A methylene group (-CH2-) attached to tetrahydrofolate is used to convert the uracil...
متن کاملBiomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid.
BACKGROUND B-vitamins (folate, B(12)) are important micronutrients for brain function and essential cofactors for homocysteine (HCY) metabolism. Increased HCY has been related to neurological and psychiatric disorders. We studied the role of the B-vitamins in HCY metabolism in the brain. METHODS We studied blood and cerebrospinal fluid (CSF) samples from 72 patients who underwent lumbar punct...
متن کاملFolate and vitamin B12 in older Australians.
The recent viewpoint by Kamien1 and letter by Gunasekera2 rightly highlight the benefits of folate fortification and the unlikely occurrence of masking pernicious anaemia. Food Standards Australia New Zealand recently submitted a proposal supporting the mandatory fortification of bread-making flour to increase folate intakes in women of child-bearing age, with the aim of reducing the risk of ch...
متن کاملFolate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome.
Increased folate intake reduces the risk of neural tube defects, other malformations and also possibly, pregnancy complications. Increasing evidence suggests that the beneficial effect of folate may be related to improved function of methionine synthase, a vitamin B12-dependent enzyme that converts homocysteine to methionine. In India, the majority of the population adheres to a vegetarian diet...
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ژورنال
عنوان ژورنال: Nutrients
سال: 2016
ISSN: 2072-6643
DOI: 10.3390/nu9010008